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  US regulators on Wednesday approved the first drug to treat obesity in 13 years, …

US regulators on Wednesday approved the first drug to treat obesity in 13 years, a drug called lorcaserin, marketed as Belviq and made by Arena Pharmaceuticals.

The drug works to control the appetite through receptors in the brain and was approved as additional therapy for certain overweight and obese patients, combined with diet and exercise.

Trials showed the drug helped people lose an average of three to 3.7 percent of their body weight after a year when compared to a placebo, the US Food and Drug Administration said.

It is approved for use in obese adults with a body mass index of 30 or greater, or overweight adults with a BMI of 27 or greater who have at least one other condition such as high blood pressure, type 2 diabetes, or high cholesterol.

Arena’s stock opened the day at $9 per share and jumped as high as 47 percent on news of the US approval. The company said it is also seeking approval on the European market, but has no timeline yet for a decision.

Janet Woodcock, director of the FDA’s Center for Drug Evaluation and Research, described obesity as “a major public health concern,” and said the new drug offers a treatment option when used “responsibly in combination with a healthy diet and lifestyle.”

However, the FDA warned that Belviq is not for women who are pregnant or nursing, and called for further long-term postmarketing studies on the drug’s potential risks.

The label will also recommend that Belviq be discontinued in patients who fail to lose five percent of their body weight after 12 weeks of treatment.

“These patients are unlikely to achieve clinically meaningful weight loss with continued treatment,” said the FDA statement.

Belviq activates the serotonin 2C receptor in the brain, and may cause serious side effects if taken in combination with certain medications for depression and migraine that increase serotonin levels or activate serotonin receptors.

“Belviq may also cause disturbances in attention or memory,” said the FDA.

Common side-effects in patients without diabetes include headache, dizziness, fatigue, nausea, dry mouth, and constipation.

In diabetic patients, side effects may include low blood sugar, headache, back pain, cough, and fatigue.

Lorcaserin was rejected in 2010 by the Endocrinologic and Metabolic Drugs Advisory Committee, which advises the FDA, over concerns that it formed breast tumors in rats.

But those effects did not appear in trials on overweight and obese humans.

An independent advisory committee to the FDA recommended the drug be approved in May after three randomized, placebo-controlled trials of nearly 8,000 patients spanning one to two years.

“All participants received lifestyle modification that consisted of a reduced calorie diet and exercise counseling,” the FDA said.

“Compared with placebo, treatment with Belviq for up to one year was associated with average weight loss ranging from three percent to 3.7 percent.”

Some patients with type 2 diabetes experienced higher levels of weight loss, with 38 percent of these patients achieving at least five percent loss of their body weight compared to 16 percent who did the same on a placebo.

The pills will be manufactured at Arena’s facility in Zofingen, Switzerland, and will be distributed in the US by Eisai Pharmaceuticals.

Arena is headquartered in San Diego, California.

According to Michael Aziz, internist at Lenox Hill Hospital in New York City, the biggest apparent drawback to the drug is the tiny amount of weight loss that patients experience while taking it.

“The only problem with this drug is the weight loss is so, so very low,” Aziz told AFP, remarking that a 200 pound (91 kilogram) person might lose just six pounds (2.7 kg) in a year, based on the study data.

“That is so insignificant,” he said. “I think people should also implement lifestyle changes because the fact is, people can lose one pound a week and that is perfectly healthy.”

The last anti-obesity drug approved in the United States was Xenical (Orlistat) by Roche in 1999.

Sold over the counter as Alli by GlaxoSmithKline, it works by preventing the body from absorbing fat, though its tendency to cause gastrointestinal side effects such as oily, loose stools have curbed its popularity among patients.

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Guide language: Private parts is the woman’s most sensitive region, also be the woman’s most crucial place. However, appear when feminine private parts dry, flabby when waiting for a problem, meet a woman bring a few awkward worries. So, how should be the woman protected for private parts wet? And of concerned private parts what to protect wet method to have?

　　

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1, physiology element

Female vagina is dry having very big concern with the age, be close to the female after the turn of life and the turn of life, estrogen level is reduced, vaginal wall tends flowing, secretion decreases , this kind dry the physiology situation that attributes nature.

Means of settlement: Female of the turn of life can drop because of level of the hormone inside menopause rear body and cause dry. If estrogen is lacked, right amount and compensatory estrogen can fall in doctor guidance.

2, psychological element

Pressure of the job, life can bring about sexual desire low, the gender calls delay, the vagina is dry.

Means of settlement: The society releases pressure. Easing pressure is “ protects wet ” , the female should learn to release psychology of pressure, society to adjust. Serious person, can look for psychological doctor to seek advice. Private parts is flabby and dry without flexibility, how to do? How should solve? >> >

　　Introduction: Proper fleshy products is helpful to reducing weight. Having beef way reducing weight is method of a kind of carnivorous reducing weight. Control the heft of delicious flesh, how does the society match food, not only can make you light light loose subtractive weight, return blood of can beautiful Yan Bu. Beef is the meat with a kind of abundant nutrition, the beneficial that raise a stomach is angry, often eat can make a person strong.

Proper fleshy products is helpful to reducing weight. Having beef way reducing weight is method of a kind of carnivorous reducing weight. Control the heft of delicious flesh, how does the society match food, not only can make you light light loose subtractive weight, return blood of can beautiful Yan Bu. Eat beef what to profit there is?

The doctor of traditional Chinese medicine thinks, beef flavour pleasant, sex is smooth, enter classics of lienal, stomach, those who have oedema of blood of gas of filling taste, beneficial, strong bones and muscles, disappear is penitentiary, very comfortable Hefei is fat person edible. The beautiful that beef is gas of the beneficial that raise a stomach is tasted, often eat can make a person strong.

Love still the net stalks of grain solely only, reprint ask give chapter and verse for!

Relevant heat: Food reducing weight eats fleshy beef reducing weight to reduce weight

Do you suffer from insomnia problems too? To see if you ignore this three details!

　　1.Exercise during the day

Daytime exercise

We all know exercise improves our health, but it also improves our sleep by reducing stress. The caveat, don’t exercise within 3 hours before bedtime. The adrenaline will keep you awake.

We all know that exercise is beneficial to health, but it also reduces the pressure to improve the quality of sleep. It should be noted that is not doing it for three hours before going to bed. Adrenaline makes you more conscious.

　　2.Remove the electronics

Turn off electronic products

Shut off the TV and remove computers and other electronic devices from your bedroom. They tempt you to engage in non-restful activities and keep you awake. The bedroom is for sleep, not work and surfing the internet.

Turn off the TV, take the computer, from your bedroom and all other electronic products are transferred out. They will make it difficult for you to rest in active, makes you stay awake. Bedrooms are used for sleeping, don’t work, or Internet access.

　　3.Read

Read

Read an entertaining or boring book. It helps to get your mind of worries and your to-do list. Stay away from stimulating or self-help books though; they rev up your brain.

Read an interesting or dull book. This can keep you away from trouble and the task table. Don’t read that self motivation books, they will make your brain is more active.

Source: hujiang English

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• Women smoke in Johannesburg on …

• Traditional leader of the bushmen …

Health authorities are working at tightening South Africa’s anti-smoking laws, proposing a total ban on indoor smoking and even making it illegal to puff away in open spaces such as beaches.

Stadiums, zoos, parks, outdoor eateries and beer gardens would all be affected. At beaches, smoking would only be allowed at least 50 metres from the closest person.

But before introducing any new law, the health ministry will throw open the proposals to the public in discussions next week.

It is the second time in five years that South Africa has tried to amend its legislation to make it even harder for smokers to indulge in their habit.

Even before the regulations are debated and final decisions made however, many smokers are fuming, labelling the plans as “extreme”, “shameless” and an intrusion on people’s rights.

“It’s a kind of hysteria, a kind of peculiar semi-religious fundamentalist puritanism,” said Leon Louw, director of the Free Market Foundation, a think tank pushing for an open society free of regulations.

“It’s a kind of vicious assault on other peoples’ choices and lifestyles.”

If the regulations went through they could constitute a breach of freedom and even result in job losses, the foundation suggests.

“The anti-tobacco fanatics… the nicotine nazis or nico-nazis obviously will not stop until it’s full prohibition,” he added.

In 2007, lawmakers approved a litany of changes that sought to close loopholes in the Tobacco Products Control Act of 1993.

On Wednesday, the Supreme Court of Appeal upheld that law’s blanket ban on tobacco ads.

It rejected a lawsuit brought by British American Tobacco SA, which had argued that the restrictions infringed on the company’s free speech rights.

Buoyed by that case, anti-smoking lobbyists are rejoicing at the latest stringent proposals.

“It goes the next step to protect health and we think it will work practically,” said Peter Ucko, director of the National Council Against Smoking.

Pro-smoking lobbyists argue that enforcing such a broad ban would be impossible, but Ucko insisted the laws will work.

Since the 2007 regulations, “no one smokes in shopping malls anymore,” he said.

Hoteliers appear unfazed by the pending changes.

“There may be certain discomfort for restaurants and pubs, but for the hotels, I don’t think there will be an impact from the revenue point of view,” said Eddie Khosa of the Federated Hospitality Association of Southern Africa. If the changes are adopted, South Africa would become the first African country to go smoke-free.

There were some 7.7 million adult tobacco users in South Africa last year, lighting up an estimated 27 billion cigarettes, according to the Tobacco Institute of Southern Africa.

But these numbers are 30-percent down on those from 10 years ago.

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  Alberto Perez, founder of Zumba Fitness, performs on stage during a meeting in Rimini, …

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  Alberto Perez, founder of Zumba Fitness, performs on stage during a meeting in Rimini, …

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  Alberto Perez (C), founder of Zumba Fitness, performs on stage during a meeting in …

•  Photo: People practice Zumba during a meeting in Rimini, central Italy May 11, 2012. Zumba, …
•  Photo: Alberto Perez, founder of Zumba Fitness, speaks on stage during a meeting in Rimini, …

MIAMI (Reuters) – Alberto Perez started out as a street performer and then an aerobics teacher in Colombia, making extra cash on the side teaching the wives of businessmen how to dance in nightclubs in his hometown, Cali.

Today, he stands at the centre of the Zumba exercise craze, having helped transform Zumba Fitness, a private company, into a rapidly growing fitness empire with heavyweight investor backing.

“I’m not a businessman, but I knew this had the potential to be something special,” said Perez, who along with two Colombian associates founded the Miami-based company.

Zumba, a Latin dance-inspired aerobic workout, has exploded from a Miami gym phenomenon to infomercial and DVD smash hit into a global craze with some 12 million people taking classes every week in at least 125 countries. Zumba Fitness now boasts being the largest branded fitness program in the world.

Started on a shoestring budget in a Miami garage nearly 11 years ago, Zumba Fitness now has more than 200 employees, and a pair of New York investment firms are betting the craze has staying power.

What began as a company focused on fitness has evolved into a lifestyle and entertainment brand combining e-commerce, apparel and music, and a sought-after outlet for stars like hip-hop artists Pitbull and Wyclef Jean and reggaeton singer Don Omar who have turned to Zumba to promote their music.

THE ACCIDENTAL INSTRUCTOR

Zumba got its start by chance in the 1980s.

Perez, who is known as Beto, was eking out a living as a street performer and salsa and merengue nightclub dancer known for his boyish model looks and muscular physique.

One day the owner of a nearby gym called and asked if Perez could stand in for an injured aerobics teacher. He agreed – but didn’t mention he had never done aerobics and rushed out and bought a copy of Jane Fonda’s Workout Book.

His fitness career was born.

Months later, getting ready for a class, Perez forgot his aerobics music. Instead, he put on his own merengue and salsa tapes and improvised dance moves for a workout, creating what today is known as Zumba.

It proved to be a hit and he quickly developed a loyal following before he moved to Bogota, where he briefly worked as a choreographer with pop star Shakira.

In 1999, Perez packed up and headed to Miami, speaking no English but hoping to make a breakthrough in the Latin-flavoured U.S. city with his new dance exercise class.

He struggled before eventually building up a large, adoring fan base of mostly Colombian expatriate women, including the mother of Alberto Perlman.

Then a technology entrepreneur, Perlman lost his job in the dot-com bust two years later and was struggling with what career move to make next. He co-founded Zumba Fitness and is now its chief executive.

“My mom had been taking his classes for years,” he said. “She would tell me about this amazing class but I never paid attention. When the bubble burst, I went to have dinner at her house and she kept saying ‘Talk to Beto, maybe you guys could start a gym.’”

“I said I’d meet with him but I wasn’t sure what I was going to do with him,” Perlman recalled. But after watching a class, he came up with the idea for a new fitness video he hoped could be an infomercial success.

The men sought to put a name on the exercise, first thinking of the Spanish word rumba, which loosely translates as party, but realized it was already trademarked.

“We just went through the alphabet to see what rhymes with rumba,” Perlman said. “We were getting nervous by the end, nothing sounded good – bumba, kumba. Then we settled on Zumba, it was perfect.”

12 MILLION AND COUNTING

Perlman said growing the instructor and student base is the firm’s top priority, with a goal of one day reaching 100 million students, more than eight times the current number.

The company has also launched its own line of brightly coloured clothing, Zumba footwear and a glossy magazine named “ZLife”, all designed in its Miami office.

But it is also focused on developing TV shows, pushing into global markets, particularly Eastern Europe, Asia and Latin America, and exploiting a new business opportunity: fitness concerts.

“I see Zumba Fitness also as an entertainment brand,” Perlman said. “It’s becoming a music, TV and concert platform.”

Fitness fads rise and fall. But two prominent investment firms have made bets Zumba Fitness will avoid going the way of workout has-beens like Jazzercise, Thighmaster and the Ab Rocket.

“You see a lot of feasts and famines in the fitness industry,” said Richard Wells, managing director of New York-based Insight Venture Partners, a private equity and venture capital firm that has invested in Twitter and Tumblr.

The firm made a minority investment in Zumba Fitness earlier this year. “They are just scratching the surface of its potential,” Wells said.

The Raine Group, a media and entertainment investment firm based in New York, also has invested in the firm.

Neither company would reveal the size of its investment.

Perlman said Zumba Fitness hopes to draw on the firms for media, entertainment and technology resources and has no plans to go public.

“While there isn’t a lot we rule out at Zumba Fitness, this is not on our radar at this time,” he said.

THE ZUMBA ECOSYSTEM

Once Zumba gained exposure on infomercials, fans started asking for more. The company began receiving calls at all hours of the day from people saying “I want to be a Zumba instructor,” said Perlman.

By 2005, the company decided to develop the global instructor network and Zumba took off. The instructors each pay $30 a month to receive regular instalments of new music and dance and exercise steps.

“It’s their ecosystem,” said Wells, the investor.

The network has turned Zumba instructors in the United States and across the globe as far away as South Korea and Norway into entrepreneurs.

“It’s become my small business,” said Betsy Dopico, a native Cuban who moved to Miami from Mexico four years ago and now teaches Zumba classes.

On a recent night, around 60 people packed a downtown Miami dance studio for her hour-long class. Salsa and merengue rhythms throbbed on loudspeakers as the group of mostly 20-something and middle-aged women in sweat-drenched T-shirts and exercise tights spun around, kicked and jumped to the music.

A handful of men also participated, most of them mimicking Dopico’s moves from the back of the class.

Mehdi Benhaddouch, a 32-year-old account executive at a financial company, said he had grown bored with gym workouts before settling on Zumba a few months ago. “It’s like going to a nightclub, but you’re exercising,” he said.

The company has turned live concerts into fitness experiences where concert-goers follow Zumba instructors on stage while artists perform.

A concert in Orlando, Florida, last year drew thousands.

“My dream is to see fitness concerts all over the world, travelling shows, permanent shows in Las Vegas,” Perlman said. “The artists love it too, because it’s a new way of selling their music.”

Success has also brought challenges. Pirated versions of Zumba Fitness DVDs and clothing have led the company to hire a staff of a dozen people to combat counterfeiting.

Perez, whose official title is “chief creative officer”, said Zumba’s explosive popularity is rooted in its simplicity of having a good time while trying to stay fit.

“Over the years, fitness became too complicated and difficult,” he said. “The industry turned egocentric with an emphasis on instructors doing the exercises. It became a show.”

He added: “They forgot about normal people – mothers, grandmothers and the housewives who want to stay in shape and have some fun. That’s the essence of Zumba.”

(Editing by David Adams and Jim Loney)

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Well-known, the woman has a very important “ conduit ” , no matter be results health, or is to enjoy pleasure, relying on its ——— is the vagina then, but what most woman knows however to the vagina is very little. because of such, this station is special invite female expert, the vagina that introduces understanding of a few need for broad female is secret.

　　

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One, the function that the vagina has ego cleanness.

All sorts of gland physical ability inside “ vagina secrete a few liquids, it can lubricate and clean vagina. ” los angeles registers Si Tan of · of senior nurse Li Sha to introduce. Those who need an attention is, when bathing excessive clean the vagina, can lay those natural lubricant and benefit bacterium is swept, bring about bacterium of oxygen of be disgusted with and mould breed, bring about secrete out of order, peculiar smell and Sao itch etc. Because this rinses vulva can, do not use the agent is rinsed inside the vagina.

2, fall in sexual excitement, the vagina is met “ lengthens ” .

Below whack, average length of the vagina is 8.5 centimeters of —12 centimeter. “ gets after sexual excitement, the vagina can be out of shape, add to double original. ” gynecologist, " the thing that can ask gynecologist only " Sa of advantage of one book author · orchid recommend, sufficient foreplay can make ” of vaginal “ cubage expands further, also can make sexual love is experienced increase ceaselessly. Private parts is flabby and dry without flexibility, how to solve? See an expert suggest >> >

　　Introduction: There perhaps is some of method reducing weight to pass buccal mouth according to legend on the network, meeting occurrence mistake. So final meeting brings about MM people cannot reduce weight effectively, add fertilizer to become the matter with fat MM instead. Crammer of what thin body cheats a female the most easily so after all? Below small make up labor these thin bodies reduce weight crammer, make everybody correct and effective thin body.

There perhaps is some of method reducing weight to pass buccal mouth according to legend on the network, meeting occurrence mistake. So final meeting brings about MM people cannot reduce weight effectively, add fertilizer to become the matter with fat MM instead. So after all crammer of what thin body cheats a female the most easily.

Fat reason 1: Period reduces weight the 14th day

Period the 14th angel is follicular period, grow in quantity of this moment estrogen, yes gastric platoon is deferred for nothing. The quantity of heat that hearsay uses up in this day is at ordinary times double, suit to eat the food of high quantity of heat that dare not eat at ordinary times, and still won’t get fat. This view is wrong. This day of reason because of estrogen grow in quantity, can abate bowel wriggles. Can become after absorbing food of high quantity of heat adipose protect existence body in.

Relevant heat: Health reduces weight effective fat reason

　Introduction: Annual dragon boat festival is coming, whenever happy festival time is little not get together with photograph of relatives and friends, small drink a few cup, food that absorb amount of tall grease high fever also unavoidable. A few does food of dragon boat festival have to need to notice, otherwise healthy problem will be following one by one after the festival passes. Make sure diet of dragon boat festival is healthy, let oneself cross a happy dragon boat festival.

Festival will come, when photograph of relatives and friends gets together little not small drink a few cups, and absorb the food that tall grease high fever measures easily. Add holiday food not to have the rule, digestion disease becomes doctor of dragon boat festival to examine most disease. To avoid to be in dragon boat festival appears healthy problem, must know below notes of these food of dragon boat festival.

1, the collocation of staple food and non-staple food

In the food of holiday, often cooked food is rich, the flesh kind very much, but too fat also. Expert proposal, during the festival, want to notice the collocation of staple food and non-staple food above all, advocate with maigre give priority to, element of meat or fish is tie-in. Element of meat or fish is tie-in and balanced the appetite that can stimulate a person, still can make sure nutrition is balanced at the same time.

Relevant heat: Food of dragon boat festival of healthy diet dragon boat festival

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  Indian pharmaceutical tycoon Yusuf Hamied in 2010. Hamied revolutionised AIDS treatment more than a decade ago by supplying cut-price drugs to the world’s poor. Now he wants to do the same for cancer. Hamied, chairman of generic drugs giant Cipla, last month slashed the cost of three medicines to fight brain, kidney and lung cancer in India, making the drugs up to more than four times cheaper

Indian pharmaceutical tycoon Yusuf Hamied revolutionised AIDS treatment more than a decade ago by supplying cut-price drugs to the world’s poor — and now he wants to do the same for cancer.

Hamied, chairman of generic drugs giant Cipla, last month slashed the cost of three medicines to fight brain, kidney and lung cancer in India, making the drugs up to more than four times cheaper.

“I hope we’ll cut prices of many more cancer drugs,” he told AFP, adding that he wants to supply the cheaper drugs to Africa and elsewhere.

“Reducing the price of cancer drugs is a humanitarian move.”

Hamied, 76, was pilloried by Western drug giants 11 years ago when he broke their monopoly by offering to supply life-saving triple therapy AIDS drug cocktails for under $1 a day — one-thirtieth the price of the multinationals.

The firms branded him an intellectual property thief while he accused them of being “global serial killers” whose high prices were costing the lives of AIDS patients.

“What he did was path-breaking. It has been very important in saving lives, and what he is doing with cancer drugs is the same,” said Leena Menghaney, a lawyer with humanitarian group Medecins sans Frontieres (Doctors Without Borders).

In 1972, India made only the process for making drugs patentable, not the drugs themselves.

This meant firms could “reverse-engineer” or change methods used to make medicines and sell them at up to one-fiftieth of US prices.

The legislation gave a huge leg-up to India’s generics industry and gave the nation the nickname “the pharmacy to the Third World”.

But in 2005, India brought its law in line with World Trade Organization (WTO) rules recognising 20-year patents, pushing up the prices of newly launched drugs.

Cipla, India’s fourth largest pharmaceutical company by sales, has been pressing the government to allow widespread use of “compulsory licences”, which are permitted under WTO rules.

The licences allow companies to make existing life-saving drugs to sell in countries where they are otherwise priced out of reach.

India’s first such licence was granted in March to Natco Pharma to produce a generic version of Bayer’s blockbuster kidney cancer drug Nexavar, cutting the price from 28,000 rupees ($500) for a monthly dose to 6,840 rupees.

Ranjit Shahani, who heads the Organisation of Pharmaceutical Producers of India, says widespread compulsory licensing will jeopardise investment in innovative pharmaceuticals.

Bayer has said it will launch a legal challenge to the compulsory licence, and global drugmakers have vowed to oppose the spread of such legislation.

Hamied denied that his latest move was simply an attempt to boost his share in the oncology drugs market, insisting business must be linked to “social responsibility”.

But he said like any other business his company, which has 23 cancer drugs, also wants higher sales.

“I owe it to my shareholders to be pragmatic,” he said.

Born in Lithuania to an Indian Muslim father and a Lithuanian Jewish mother, Hamied was two months old when his parents fled Europe in the 1930s under the threat of Nazi Germany.

He was raised in Mumbai and studied for a doctorate in chemistry at Cambridge University in Britain before joining Cipla, which was founded by his father.

“My father never forced me but chemistry was my best subject,” said Hamied, who became chairman of the company in 1989.

His bold step in offering cheap AIDS drugs turned out to be a smart business move.

Cipla is now the world’s largest AIDS antiretroviral drugs supplier and the publicly-listed company is valued at nearly $5 billion, while business magazine Forbes puts Hamied’s personal fortune at $1.75 billion.

But Hamied said poverty-racked India “can’t afford to divide people into those who can afford life-saving drugs and those who can’t”.

“It needs a pragmatic policy,” he said.

He believes the pharma giants should let emerging market drugmakers make copycat medicines in exchange for small royalties.

Some 95 percent of Western firms’ profits come from regulated developed markets like Japan, Europe, America, so the pharmaceutical giants “really won’t lose out”, he said.

Even with the reduced price of generic drugs, such medicines are still beyond the reach of many of the world’s poorest, conceded Hamied, who confesses he has his eye on his legacy.

“I want it to be said when I leave this world that ‘he was not just a money-making machine,’” he said.

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